Genetic testing of allelic variants of PIZ (GLU342Lys, RS28929474) and PIS (GLU264Val, RS17580) of SERPINA1 gene in children with bronchial asthma

According to world publications, mutations in the SERPINA1 gene may be a genetic risk factor for severe chronic obstructive pulmonary disease and, consequently, rapid progression of respiratory dysfunction. This leads decrease level alpha-1-antitrypsin protein. It is inherited by autosomal recessive type, but there are registered cases codominance. In absence treatment, diseases system become and lead disability adulthood.
 Early diagnosis AAT deficiency important prevent complications reduce mortality among people with this pathology. Due these factors, testing children lung appropriate detect complications, associated AATD.
 The aim work improve effectiveness early bronchial asthma recurrent bronchitis identifying different genotypes phenotypes A1AT deficiency, studying their relationship clinical course